Publications

Google Scholar

ResearchGate

Publications: List

In vivo/in vitro cardiac disease models

(corresponding author) Zakaria, Zain Zaki., Eisa-Beygi, Shahram, Benslimane, Fatiha M., Ramchandran, Ramani, Yalcin, Huseyin C., 2022. Design and Microinjection of Morpholino Antisense Oligonucleotides and mRNA into Zebrafish Embryos to Elucidate Specific Gene Function in Heart Development in JoVE's Developmental Biology. (186), e63324.
Gupta, A., Thirugnanam, K., Thamilarasan, M., Mohieldin, A.M., Zedan, H.T., Prabhudesai, S., Griffin, M.R., Spearman, A.D., Pan, A., Palecek, S.P. and Yalcin, H.C., 2022. Cilia proteins are biomarkers of altered flow in the vasculature. JCI insight, 7(6).
(corresponding author) Alser, M., Salman, H.E., Naïja, A., Seers, T.D., Khan, T. and Yalcin, H.C., 2022. Blood Flow Disturbance and Morphological Alterations Following the Right Atrial Ligation in the Chick Embryo. Frontiers in Physiology, p.499.
Zakaria, Z.Z., Aladwi, S.A., Benslimane, F., Al-Absi, E.S., Al-Shafai, M., Yalcin, H.C., Khalil, A., Moustafa, A.E.A. and Al-Asmakh, M., 2021. Effect of Water-Pipe Smoking on the Normal Development of Zebrafish. International Journal of Environmental Research and Public Health, 18(21), p.11659.
(corresponding author) Al-Ruweidi, M.K.A., Ali, F.H., Shurbaji, S., Popelka, A. and Yalcin, H.C., 2021. Dexamethasone and transdehydroandrosterone significantly reduce pulmonary epithelial cell injuries associated with mechanical ventilation. Journal of Applied Physiology.
(corresponding author) Salman, H.E., Alser, M., Shekhar, A., Gould, R.A., Benslimane, F.M., Butcher, J.T. and Yalcin, H.C., 2021. Effect of left atrial ligation-driven altered inflow hemodynamics on embryonic heart development: clues for prenatal progression of hypoplastic left heart syndrome. Biomechanics and Modeling in Mechanobiology, 20(2), pp.733-750.
(corresponding author) Alser, M., Shurbaji, S. and Yalcin, H.C., 2021. Mechanosensitive pathways in heart development: findings from chick embryo studies. Journal of Cardiovascular Development and Disease, 8(4), p.32.
Abdulrahman, N., Siveen, K.S., Joseph, J.M., Osman, A., Yalcin, H.C., Hasan, A., Uddin, S. and Mraiche, F., 2020. Inhibition of p90 ribosomal S6 kinase potentiates cisplatin activity in A549 human lung adenocarcinoma cells. Journal of Pharmacy and Pharmacology, 72(11), pp.1536-1545.
Da'as, S.I., Yalcin, H.C., Nasrallah, G.K., Mohamed, I.A., Nomikos, M., Yacoub, M.H. and Fakhro, K.A., 2020. Functional characterization of human myosin‐binding protein C3 variants associated with hypertrophic cardiomyopathy reveals exon‐specific cardiac phenotypes in zebrafish model. Journal of Cellular Physiology, 235(11), pp.7870-7888.
(corresponding author) Shurbaji, S., Al-Ruweidi, M.K.A., Ali, F.H., Benslimane, F.M. and Yalcin, H.C., 2020. Application of a flow-induced stress wave and investigation of associated injuries on cell monolayers using a parallel plate flow chamber. Methods and Protocols, 3(4), p.65.
(corresponding author) Benslimane, F.M., Zakaria, Z.Z., Shurbaji, S., Abdelrasool, M.K.A., Al-Badr, M.A.H., Al Absi, E.S.K. and Yalcin, H.C., 2020. Cardiac function and blood flow hemodynamics assessment of zebrafish (Danio rerio) using high-speed video microscopy. Micron, 136, p.102876.
(corresponding author) Salman, H.E. and Yalcin, H.C., 2020. Advanced blood flow assessment in Zebrafish via experimental digital particle image velocimetry and computational fluid dynamics modeling. Micron, 130, p.102801.
Augustine, R., Alhussain, H., Hasan, A., Ahmed, M.B., Yalcin, H.C. and Al Moustafa, A.E., 2020. A novel in ovo model to study cancer metastasis using chicken embryos and GFP expressing cancer cells. Bosnian Journal of Basic Medical Sciences, 20(1), p.140.
(corresponding author) Yalcin, H.C., Benslimane, F.M. and Kawakami, K., 2019. The First International Zebrafish Conference/Workshop in Qatar. Zebrafish, 16(5), pp.493-495.
(corresponding author) Benslimane, F.M., Alser, M., Zakaria, Z.Z., Sharma, A., Abdelrahman, H.A. and Yalcin, H.C., 2019. Adaptation of a mice doppler echocardiography platform to measure cardiac flow velocities for embryonic chicken and adult zebrafish. Frontiers in bioengineering and biotechnology, 7, p.96.
Eisa-Beygi, S., Benslimane, F.M., El-Rass, S., Prabhudesai, S., Abdelrasoul, M.K.A., Simpson, P.M., Yalcin, H.C., Burrows, P.E. and Ramchandran, R., 2018. Characterization of endothelial cilia distribution during cerebral-vascular development in zebrafish (Danio rerio). Arteriosclerosis, thrombosis, and vascular biology, 38(12), pp.2806-2818.
(corresponding author) Zakaria, Z.Z., Benslimane, F.M., Nasrallah, G.K., Shurbaji, S., Younes, N.N., Mraiche, F., Da’as, S.I. and Yalcin, H.C., 2018. Using zebrafish for investigating the molecular mechanisms of drug-induced cardiotoxicity. BioMed research international, 2018.
Alahmad, Y.M., Aljaber, M., Saleh, A.I., Yalcin, H.C., Aboulkassim, T., Yasmeen, A., Batist, G. and Moustafa, A.E.A., 2018. Effect of cell‐phone radiofrequency on angiogenesis and cell invasion in human head and neck cancer cells. Head & Neck, 40(10), pp.2166-2171.
Ashour, A.A., Haik, M.Y., Sadek, K.W., Yalcin, H.C., Bitharas, J., Aboulkassim, T., Batist, G., Yasmeen, A. and Al Moustafa, A.E., 2018. Substantial toxic effect of water-pipe smoking on the early stage of embryonic development. Nicotine and Tobacco Research, 20(4), pp.502-507.
Saleh, A.I., Mohamed, I., Mohamed, A.A., Abdelkader, M., Yalcin, H.C., Aboulkassim, T., Batist, G., Yasmeen, A. and Moustafa, A.E.A., 2018. Elaeagnus angustifolia plant extract inhibits angiogenesis and downgrades cell invasion of human oral cancer cells via Erk1/Erk2 inactivation. Nutrition and cancer, 70(2), pp.297-305.
(corresponding author) Yalcin, H.C., 2018. Hemodynamic studies for analyzing the teratogenic effects of drugs in the zebrafish embryo. In Teratogenicity Testing (pp. 487-495). Humana Press, New York, NY.
(corresponding author) Yalcin, H.C., Amindari, A., Butcher, J.T., Althani, A. and Yacoub, M., 2017. Heart function and hemodynamic analysis for zebrafish embryos. Developmental Dynamics, 246(11), pp.868-880.
Gould, R.A., Yalcin, H.C., MacKay, J.L., Sauls, K., Norris, R., Kumar, S. and Butcher, J.T., 2016. Cyclic mechanical loading is essential for Rac1-mediated elongation and remodeling of the embryonic mitral valve. Current Biology, 26(1), pp.27-37.
Lindsey, S.E., Menon, P.G., Kowalski, W.J., Shekhar, A., Yalcin, H.C., Nishimura, N., Schaffer, C.B., Butcher, J.T. and Pekkan, K., 2015. Growth and hemodynamics after early embryonic aortic arch occlusion. Biomechanics and modeling in mechanobiology, 14(4), pp.735-751.
(corresponding author) Yalcin, H.C., 2014. Femtosecond laser photodisruption of vitelline vessels of avian embryos as a technique to study embryonic vascular remodeling. Experimental biology and medicine, 239(12), pp.1644-1652.
(corresponding author) Lindsey, S.E., Butcher, J.T. and Yalcin, H.C., 2014. Mechanical regulation of cardiac development. Frontiers in physiology, 5, p.318.
Bharadwaj, K.N., Spitz, C., Shekhar, A., Yalcin, H.C. and Butcher, J.T., 2012. Computational fluid dynamics of developing avian outflow tract heart valves. Annals of biomedical engineering, 40(10), pp.2212-2227.
Henning, A.L., Jiang, M.X., Yalcin, H.C. and Butcher, J.T., 2011. Quantitative three‐dimensional imaging of live avian embryonic morphogenesis via micro‐computed tomography. Developmental Dynamics, 240(8), pp.1949-1957.
Yalcin, H.C., Shekhar, A., McQuinn, T.C. and Butcher, J.T., 2011. Hemodynamic patterning of the avian atrioventricular valve. Developmental Dynamics, 240(1), pp.23-35.
Yalcin, H.C., Shekhar, A., Nishimura, N., Rane, A.A., Schaffer, C.B. and Butcher, J.T., 2010. Two-photon microscopy-guided femtosecond-laser photoablation of avian cardiogenesis: noninvasive creation of localized heart defects. American journal of physiology-Heart and circulatory physiology, 299(5), pp.H1728-H1735.
Yalcin, H.C., Shekhar, A., Rane, A.A. and Butcher, J.T., 2010. An ex-ovo chicken embryo culture system suitable for imaging and microsurgery applications. JoVE (Journal of Visualized Experiments), (44), p.e2154.
Yalcin, H.C., Hallow, K.M., Wang, J., Wei, M.T., Ou-Yang, H.D. and Ghadiali, S.N., 2009. Influence of cytoskeletal structure and mechanics on epithelial cell injury during cyclic airway reopening. American Journal of Physiology-Lung Cellular and Molecular Physiology, 297(5), pp.L881-L891.
Wei, M.T., Zaorski, A., Yalcin, H.C., Wang, J., Hallow, M., Ghadiali, S.N., Chiou, A. and Ou-Yang, H.D., 2008. A comparative study of living cell micromechanical properties by oscillatory optical tweezers. Optics express, 16(12), pp.8594-8603.
Yalcin, H.C., Perry, S.F. and Ghadiali, S.N., 2007. Influence of airway diameter and cell confluence on epithelial cell injury in an in vitro model of airway reopening. Journal of Applied Physiology, 103(5), pp.1796-1807
Numerical Simulation of Cardiovascular Flows
(corresponding author) Salman, H.E., Kamal, R.Y., Hijazi, Z.M. and Yalcin, H.C., 2022. Hemodynamic and Structural Comparison of Human Fetal Heart Development Between Normally Growing and Hypoplastic Left Heart Syndrome-Diagnosed Hearts. Frontiers in Physiology, 13.
(corresponding author) Salman, H.E., Saltik, L. and Yalcin, H.C., 2021. Computational analysis of wall shear stress patterns on calcified and bicuspid aortic valves: Focus on radial and coaptation patterns. Fluids, 6(8), p.287.
(corresponding author) Mutlu, O., Salman, H.E., Yalcin, H.C. and Olcay, A.B., 2021. Fluid flow characteristics of healthy and calcified aortic valves using three-dimensional Lagrangian coherent structures analysis. Fluids, 6(6), p.203.
(corresponding author) Salman, H.E. and Yalcin, H.C., 2021. Computational modeling of blood flow hemodynamics for biomechanical investigation of cardiac development and disease. Journal of Cardiovascular Development and Disease, 8(2), p.14.
(corresponding author) Salman, H.E., Kamal, R.Y. and Yalcin, H.C., 2021. Numerical Investigation of the Fetal Left Heart Hemodynamics During Gestational Stages. Frontiers in Physiology, 12.
(corresponding author) Salman, H.E., Ramazanli, B., Yavuz, M.M. and Yalcin, H.C., 2019. Biomechanical investigation of disturbed hemodynamics-induced tissue degeneration in abdominal aortic aneurysms using computational and experimental techniques. Frontiers in bioengineering and biotechnology, 7, p.111.
(corresponding author) Olcay, A.B., Amindari, A., Kirkkopru, K. and Yalcin, H.C., 2018. Characterization of disturbed hemodynamics due to stenosed aortic jets with a Lagrangian Coherent structures technique.
(corresponding author) Amindari, A., Saltik, L., Kirkkopru, K., Yacoub, M. and Yalcin, H.C., 2017. Assessment of calcified aortic valve leaflet deformations and blood flow dynamics using fluid-structure interaction modeling. Informatics in Medicine Unlocked, 9, pp.191-199.
Dailey, H.L., Ricles, L.M., Yalcin, H.C. and Ghadiali, S.N., 2009. Image-based finite element modeling of alveolar epithelial cell injury during airway reopening. Journal of Applied Physiology, 106(1), pp.221-232.
Dailey, H.L., Yalcin, H.C. and Ghadiali, S.N., 2007. Fluid-structure modeling of flow-induced alveolar epithelial cell deformation. Computers & structures, 85(11-14), pp.1066-1071.
Machine Learning Systems for CVD diagnosis and therapy planning
(corresponding author) Boughorbel, S., Himeur, Y., Salman, H.E., Bensaali, F., Farooq, F. and Yalcin, H.C., 2022. Applications of Machine Learning for Predicting Heart Failure. Predicting Heart Failure: Invasive, Non‐Invasive, Machine Learning and Artificial Intelligence Based Methods, pp.171-188.
Maurya, M.R., Riyaz, N.U., Reddy, M., Yalcin, H.C., Ouakad, H.M., Bahadur, I., Al-Maadeed, S. and Sadasivuni, K.K., 2021. A review of smart sensors coupled with Internet of Things and Artificial Intelligence approach for heart failure monitoring. Medical & Biological Engineering & Computing, 59(11), pp.2185-2203.
Cardiac Tissue Engineering
(corresponding author) Yalcin, H.C. and Kaushik, A., 2021. Support of intelligent emergent materials to combat COVID-19 pandemic. Emergent Materials, 4(1), pp.1-2.
Augustine, R., Hasan, A., Dalvi, Y.B., Rehman, S.R.U., Varghese, R., Unni, R.N., Yalcin, H.C., Alfkey, R., Thomas, S. and Al Moustafa, A.E., 2021. Growth factor loaded in situ photocrosslinkable poly (3-hydroxybutyrate-co-3-hydroxyvalerate)/gelatin methacryloyl hybrid patch for diabetic wound healing. Materials Science and Engineering: C, 118, p.111519.
Lamprou, D., Liu, X., Ballard, Z., Yalcin, H.C., Meredith, C., Sadtler, K. and Ali, A.M.A., 2020. Materials Against COVID-19: How Materials Science can Impact the Pandemic?
(corresponding author) Zadeh, K.M., Luyt, A.S., Zarif, L., Augustine, R., Hasan, A., Messori, M., Hassan, M.K. and Yalcin, H.C., 2019. Electrospun polylactic acid/date palm polyphenol extract nanofibres for tissue engineering applications. Emergent Materials, 2(2), pp.141-151.
Abbas, T.O., Yalcin, H.C. and Pennisi, C.P., 2019. From acellular matrices to smart polymers: degradable scaffolds that are transforming the shape of urethral tissue engineering. International Journal of Molecular Sciences, 20(7), p.1763.
Hasan, A., Soliman, S., El Hajj, F., Tseng, Y.T., Yalcin, H.C. and Marei, H.E., 2018. Fabrication and in vitro characterization of a tissue engineered PCL-PLLA heart valve. Scientific reports, 8(1), pp.1-13.
Nanomedicine for CVDs
(corresponding author) Al-Thani, H.F., Shurbaji, S., Zakaria, Z.Z., Hasan, M.H., Goracinova, K., Korashy, H.M. and Yalcin, H.C., 2022. Reduced Cardiotoxicity of Ponatinib-Loaded PLGA-PEG-PLGA Nanoparticles in Zebrafish Xenograft Model. Materials, 15(11), p.3960.
(corresponding author) Al-Ansari, D.E., Al-Badr, M., Zakaria, Z.Z., Mohamed, N.A., Nasrallah, G.K., Yalcin, H.C. and Abou-Saleh, H., 2022. Evaluation of Metal‐Organic Framework MIL-89 nanoparticles toxicity on embryonic zebrafish development. Toxicology Reports, 9, pp.951-960.
(corresponding author) Al-Thani, H.F., Shurbaji, S. and Yalcin, H.C., 2021. Zebrafish as a Model for Anticancer Nanomedicine Studies. Pharmaceuticals, 14(7), p.625.
(corresponding author) Shurbaji, S., Manaph, N.P.A., Ltaief, S.M., Al-Shammari, A.R., Elzatahry, A. and Yalcin, H.C., 2021. Characterization of MXene as a cancer photothermal agent under physiological conditions. Frontiers in Nanotechnology, p.63.
(corresponding author) Shurbaji, S., El-Sherbiny, I.M., Alser, M., Ali, I.H., Kordi, H., Al-Sadi, A., Popelka, A., Benslimane, F., Yacoub, M. and Yalcin, H.C., 2021. Nitric oxide releasing hydrogel nanoparticles decreases epithelial cell injuries associated with airway reopening. Frontiers in bioengineering and biotechnology, 8, p.579788.
(corresponding author) Shurbaji, S., G. Anlar, G., A. Hussein, E., Elzatahry, A. and Yalcin, H.C., 2020. Effect of flow-induced shear stress in nanomaterial uptake by cells: Focus on targeted anti-cancer therapy. Cancers, 12(7), p.1916.
Cardiac Biomarkers, Biosensors and Microfluidic Systems
(corresponding author) A. Elrayess, M., T. Zedan, H., A. Alattar, R., Abusriwil, H., Al-Ruweidi, M.K.A., Almuraikhy, S., Parengal, J., Alhariri, B., Yassine, H.M., A. Hssain, A. Nair, A., …. and Yalcin, H.C. 2022. Soluble ACE2 and angiotensin II levels are modulated in hypertensive COVID-19 patients treated with different antihypertension drugs. Blood Pressure, 31(1), pp.80-90.
(corresponding author) Salman, H.E., Al‐Ruweidi, M.K.A., Ouakad, H.M. and Yalcin, H.C., 2022. Minimally Invasive and Non‐Invasive Sensor Technologies for Predicting Heart Failure: An Overview. Predicting Heart Failure: Invasive, Non‐Invasive, Machine Learning and Artificial Intelligence Based Methods, pp.109-138.
Sadasivuni, K.K., Ouakad, H.M., Al-Maadeed, S., Yalcin, H.C. and Bahadur, I.B. eds., 2022. Predicting Heart Failure: Invasive, Non-Invasive, Machine Learning, and Artificial Intelligence Based Methods. John Wiley & Sons.
Sukumaran, V., Gurusamy, N., Yalcin, H.C. and Venkatesh, S., 2021. Understanding diabetes-induced cardiomyopathy from the perspective of renin angiotensin aldosterone system. Pflügers Archiv-European Journal of Physiology, pp.1-19.
Al-Shamasi, A.A., Elkaffash, R., Mohamed, M., Rayan, M., Al-Khater, D., Gadeau, A.P., Ahmed, R., Hasan, A., Eldassouki, H., Yalcin, H.C. and Abdul-Ghani, M., 2021. Crosstalk between Sodium–Glucose Cotransporter Inhibitors and Sodium–Hydrogen Exchanger 1 and 3 in Cardiometabolic Diseases. International journal of molecular sciences, 22(23), p.12677.
(corresponding author) Yalcin, H.C., Sukumaran, V., Al-Ruweidi, M.K.A. and Shurbaji, S., 2021. Do changes in ace-2 expression affect SARS-CoV-2 virulence and related complications: A closer look into membrane-bound and soluble forms. International Journal of Molecular Sciences, 22(13), p.6703.
Tarim, E.A., Karakuzu, B., Oksuz, C., Sarigil, O., Kizilkaya, M., Al-Ruweidi, M.K.A., Yalcin, H.C., Ozcivici, E. and Tekin, H.C., 2021. Microfluidic-based virus detection methods for respiratory diseases. Emergent Materials, 4(1), pp.143-168.
Suleiman, M., Abdulrahman, N., Yalcin, H.C. and Mraiche, F., 2018. The role of CD44, hyaluronan and NHE1 in cardiac remodeling. Life sciences, 209, pp.197-201.

Publications: About